Research-backed supplements that may help manage symptoms and promote overall well-being during cannabis detox and post-acute withdrawal syndrome (PAWS).

The following recommendations are not only supported by science but also informed by our positive experiences working with hundreds of people recovering from chemical dependencies. Unique product links and specific brands are frequently updated for the best quality, pricing and availability. Each item is a trusted brand we endorse.

[Check with your healthcare provider before starting any herbal or nutritional supplements]


L-Theanine, an amino acid found in tea leaves, offers valuable anxiety relief and sleep support during cannabis detox.

Anxiety and sleep disturbances are common symptoms of cannabis withdrawal. L-Theanine promotes relaxation by increasing the production of calming neurotransmitters like GABA and serotonin. This, in turn, helps alleviate anxiety and provides a sense of tranquility during the detox process.

Additionally, L-Theanine can support better sleep quality by promoting the release of alpha brainwaves, which induce a state of relaxation conducive to falling asleep and staying asleep.

Recommended dose: 200 – 600 mg per day in divided doses

How it Helps

  • Provides anxiety relief during cannabis detox
  • Supports better sleep quality for improved rest during withdrawal
  • Promotes relaxation and tranquility during the detox process

Magnesium Glycinate

Magnesium Glycinate offers valuable muscle relaxation and stress reduction support.

During the acute and post-acute withdrawal, muscle tension and stress are usually prevalent. Magnesium Glycinate, a highly absorbable form of magnesium, helps relax muscles and reduces muscle cramps or discomfort associated with the detox process.

Also, magnesium plays a role in stress reduction by regulating cortisol levels, the hormone responsible for the body’s stress response. Adequate magnesium levels can help mitigate feelings of anxiety and promote a calmer state of mind during the first few months.

RECOMMENDED DOSE: 200-400 mg per day

How it Helps

  • Promotes relaxation and eases muscle tension
  • Potential alleviation of anxiety symptoms during withdrawal
  • Supports sleep quality and duration
  • Plays a crucial role in various physiological processes


GABA (Gamma-Aminobutyric Acid) is a calming neurotransmitter that can be beneficial for relaxation and anxiety relief.

Withdrawal from cannabis may lead to heightened feelings of anxiety and restlessness. GABA acts as a natural inhibitory neurotransmitter, counteracting excitatory signals in the brain and promoting a sense of calmness. By incorporating GABA supplementation, someone may experience reduced anxiety and a greater sense of relaxation throughout the process.

Additionally, GABA’s calming effects extend to its potential to alleviate sleep disturbances that may arise during withdrawal. By promoting restful sleep, GABA can aid in the recovery process, allowing the body and mind to heal more effectively.

Amount : 1000 – 3000 mg per day in divided doses

How it Helps

  • Promotes relaxation and reduces anxiety during cannabis detox
  • Acts as a natural calming neurotransmitter to counteract excitatory signals
  • Aids in alleviating sleep disturbances for more restful recovery


B Complex, a group of essential B vitamins, provides crucial nervous system support and helps maintain mood balance during cannabis detox.

During the withdrawal phase, the nervous system may experience imbalances and heightened sensitivity. B vitamins, including B1 (thiamine), B3 (niacin), B6 (pyridoxine), and B12 (cobalamin), play a role in supporting nerve health and neurotransmitter function.

Additionally, B vitamins are essential for the production of serotonin and other mood-regulating neurotransmitters. By maintaining adequate B Complex levels, people can help stabilize mood and reduce feelings of irritability or depression often experienced during cannabis withdrawal.

RECOMMENDED DOSE: 1 – 3 tablets per day

How It Helps

  • Supports the nervous system function
  • Enhances energy production and reduces fatigue
  • Promotes emotional stability and mood balance
  • Assists in the synthesis of neurotransmitters

Vitamin c

Vitamin C plays a role as an essential cofactor for neurotransmitter production, making it a recommended addition to most supplement protocols.

Neurotransmitters are chemical messengers that facilitate communication between nerve cells. As the body undergoes withdrawal, neurotransmitter imbalances can occur, leading to mood fluctuations and emotional challenges.

Vitamin C is a key component in the synthesis of neurotransmitters like dopamine and serotonin. By ensuring adequate vitamin C levels, we can support the production of these crucial neurotransmitters, promoting a more stable and positive mood throughout the detox process.

RECOMMENDED DOSE: 500 – 2000 mg per day in divided doses

How it Helps

  • Acts as a cofactor for neurotransmitter synthesis
  • Supports the production of dopamine and serotonin for mood stability
  • Provides antioxidant protection to the brain during cannabis detox


Saffron, a spice, offers mood-elevating properties that can be helpful for easing depression during the early-mid stages of detox.

Withdrawal from cannabis may lead to fluctuations in mood, including feelings of sadness and depression. Saffron contains bioactive compounds that influence serotonin levels, the neurotransmitter associated with mood regulation. By incorporating saffron supplementation, someone may experience a natural lift in mood and find relief from depressive symptoms throughout the detoxification journey.

Note: Consult with a healthcare professional before considering saffron supplementation, especially if you have specific health conditions or are taking anti-depressant medications.

RECOMMENDED DOSE: Follow dosing instructions on package label

How It Helps

  • Promotes relaxation and eases restlessness
  • Alleviates anxiety symptoms during withdrawal
  • Supports healthy sleep patterns and improves sleep quality
  • Contributes to a greater sense of ease and tranquility


Omega-3 provides essential nourishment for neurological health, making it a valuable supplement during cannabis detox.

The withdrawal phase may affect brain function, causing cognitive challenges and emotional fluctuations. Omega-3 fatty acids, particularly EPA and DHA, are fundamental building blocks of brain cells and support optimal neural function.

By adding Omega-3 supplementation, we can nourish the neurological pathways, promoting mental clarity and focus during the detoxification journey.

Additionally, Omega-3’s neurological benefits extend to mood regulation and emotional well-being. These fatty acids play a role in serotonin production, the neurotransmitter responsible for regulating mood and promoting a sense of calm.

RECOMMENDED DOSE:  2000 Р3000 mg total EPA/DHA

How it Helps

  • Supports optimal neurological function and cognitive health
  • Promotes mental clarity and focus during cannabis detox
  • Contributes to mood regulation and emotional balance


Rhodiola, an adaptogenic herb, offers fatigue-fighting properties to combat exhaustion and boost energy during cannabis detox.

By incorporating Rhodiola Rosea, it might help combat fatigue and uplift energy levels during the detox process.

Also, Rhodiola’s adaptogenic effects extend to its ability to enhance cognitive function and focus. By supporting mental clarity and alertness, Rhodiola can help people maintain better concentration and mental sharpness during withdrawal.

RECOMMENDED DOSE: 750 – 3000 mg per day in divided doses

How It Helps

  • Combats fatigue and boosts energy during cannabis detox
  • Acts as an adaptogen to promote physical and mental endurance
  • Enhances cognitive function and mental clarity
  • Note : It is typically recommended to take only one adaptogenic herb at a time.

Valerian root

Valerian Root, a natural sedative, offers relaxation and sleep support during cannabis detox.

Withdrawal from cannabis can lead to increased restlessness and sleep disturbances. Valerian Root contains compounds that interact with GABA receptors in the brain, promoting a calming effect and aiding in relaxation. By adding Valerian Root to your regimen, you might experience reduced anxiety and improved tranquility during the detoxification process.

Additionally, Valerian Root’s sedative properties extend to its potential to improve sleep quality and duration. By promoting restful sleep, Valerian Root can be instrumental in facilitating the body’s healing and recovery.

RECOMMENDED DOSE: Follow dosing instructions on package label

How It Helps

  • Promotes relaxation and anxiety relief during cannabis detox
  • Interacts with GABA receptors for a calming effect
  • Improves sleep quality and duration

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Please note: Dosage, frequency, duration, and combination recommendations of all listed products vary considerably depending upon your unique situation and needs. Check with your healthcare provider before starting any herbal or nutritional supplements, as they may interact with medications or exacerbate certain disease states.

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