Research-backed supplements that may help manage symptoms and promote overall well-being during Kratom detox and post-acute withdrawal syndrome (PAWS).

The following recommendations are not only supported by science but also informed by our positive experiences working with hundreds of people recovering from chemical dependencies. Unique product links and specific brands are frequently updated for the best quality, pricing and availability. Each item is a trusted brand we endorse.

[Check with your healthcare provider before starting any herbal or nutritional supplements]


Agmatine is an NMDA receptor modulator that can be beneficial for managing Kratom withdrawal.

Kratom is widely used for its analgesic and mood-enhancing properties, but regular use can lead to tolerance, reducing its effectiveness over time. Agmatine helps mitigate this issue by modulating NMDA receptors, which play a crucial role in the development of tolerance to certain substances.

Also, Agmatine also has potential analgesic and mood-enhancing effects of its own, making it a valuable supplement to support overall well-being during a Kratom taper or discontinuation.

Recommended dose: 500 – 2500 mg per day in divided doses

How it Helps

  • NMDA receptor modulation for Kratom taper management
  • Potential analgesic and mood-enhancing effects
  • Supportive aid for overall well-being during Kratom withdrawal

Magnesium Glycinate

Magnesium glycinate is a form of magnesium known for its calming and relaxing properties. It’s involved in over 300 enzymatic reactions in the body and plays a crucial role in various physiological processes.

During a kratom detox, symptoms such as anxiety, muscle tension, and restlessness can be common. Supplementing with magnesium glycinate can help promote relaxation, ease muscle tension, and potentially alleviate some of the discomfort associated with withdrawal.

Additionally, magnesium glycinate may support sleep quality, as insomnia is a common symptom experienced during the first few weeks and months.

RECOMMENDED DOSE: 200-400 mg per day

How it Helps

  • Promotes relaxation and eases muscle tension
  • Potential alleviation of anxiety symptoms during withdrawal
  • Supports sleep quality and duration
  • Plays a crucial role in various physiological processes


DL-Phenylalanine, commonly known as DLPA, is an amino acid supplement that may have mood-enhancing properties and aid in alleviating discomfort during withdrawal.

DLPA is a combination of two forms of phenylalanine: D-phenylalanine and L-phenylalanine. D-phenylalanine is believed to support the production of endorphins, the body’s natural feel-good chemicals, which may help elevate mood and promote a sense of well-being.

Additionally, L-phenylalanine is a precursor to various neurotransmitters, including dopamine, norepinephrine, and epinephrine, which are involved in regulating mood and managing pain perception. Supplementing with DLPA can help support the production of these neurotransmitters, potentially alleviating discomfort and promoting a more positive outlook during detox and protracted withdrawal.

It’s important to note that DLPA may interact with certain medications, such as monoamine oxidase inhibitors (MAOIs) or selective serotonin reuptake inhibitors (SSRIs). Therefore, it’s crucial to consult with a healthcare professional before considering DLPA supplementation.

RECOMMENDED DOSE : 500 – 2000 mg per day in divided doses

How it Helps

  • Supports mood enhancement and promotes a positive outlook
  • Aids in managing pain perception during withdrawal
  • Supports the production of neurotransmitters involved in mood regulation
  • Potential alleviation of discomfort associated with kratom withdrawal
  • Note: Consult with a healthcare professional before taking DLPA, especially if you are on medication


B Complex, a combination of essential B vitamins, provides support for energy and mood.

Kratom is often sought after for its mood-enhancing and energizing effects. However, frequent use can lead to a depletion of certain B vitamins, which are essential for maintaining energy levels and supporting a stable mood.

B Complex supplementation helps replenish these vital nutrients, supporting the body’s energy production and promoting a more balanced mood.

Additionally, B vitamins play a crucial role in neurotransmitter synthesis, contributing to enhanced cognitive function and overall well-being during Kratom taper and discontinuation.

RECOMMENDED DOSE: 1 – 3 tablets per day

How It Helps

  • Supports the nervous system function
  • Enhances energy production and reduces fatigue
  • Promotes emotional stability and mood balance
  • Assists in the synthesis of neurotransmitters
  • Contributes to overall well-being during withdrawal

Vitamin c

Vitamin C plays a crucial role in providing detox support and acting as a potent antioxidant, helping combat oxidative stress and reduce inflammation associated with the withdrawal process.

Also, Vitamin C aids in the elimination of toxins from the body, supporting the detoxification process and promoting a smoother transition during acute and post-acute Kratom withdrawal.

RECOMMENDED DOSE: 500 – 2000 mg per day in divided doses

How it Helps

  • Detox support by aiding in toxin elimination
  • Potent antioxidant to reduce oxidative stress
  • Boosts immune system for better withdrawal resilience


L-Tyrosine serves as a precursor to key neurotransmitters, providing support for mood and cognitive function.

During the withdrawal phase, the body may experience imbalances in certain neurotransmitters. L-Tyrosine supports the synthesis of dopamine, norepinephrine, and epinephrine, which play vital roles in mood regulation and cognitive performance.

By providing this precursor, L-Tyrosine helps to alleviate symptoms of low energy, cognitive fog, and mood fluctuations that may occur during Kratom withdrawal.

RECOMMENDED DOSE: 750 – 3000 mg per day in divided doses

How It Helps

  • Supports neurotransmitter production for improved mood and mental clarity
  • Helps manage stress levels during withdrawal
  • Aids in the body’s stress response system
  • Potential alleviation of low mood, fatigue, and difficulties with focus
  • Note: Consult with a healthcare professional before considering L-Tyrosine supplementation, especially if you have specific health conditions or are taking other medications.


Omega-3 fatty acids provide support for reducing inflammation and promoting brain health.

During the withdrawal phase, the body may experience increased inflammation due to various factors. Omega-3s, particularly EPA and DHA, possess anti-inflammatory properties that help lessen this discomfort.

Also, Omega-3s play a vital role in maintaining brain health and cognitive function. They are essential components of cell membranes in the brain, supporting neurotransmitter signaling and enhancing cognitive performance.

RECOMMENDED DOSE:  2000 Р3000 mg total EPA/DHA

How it Helps

  • Supports brain health and cognitive function
  • Reduces inflammation in the body
  • Potential mood improvement and decreased symptoms of depression


Turmeric, with its active compound curcumin, offers natural anti-inflammatory properties and mood support.

Kratom detox often causes discomfort and increased inflammation in the body. Turmeric’s curcumin content acts as a natural anti-inflammatory, helping to alleviate these symptoms and support a more comfortable withdrawal experience.

Additionally, curcumin has been shown to have positive effects on mood and mental well-being. By promoting the production of serotonin and dopamine, it may help lift mood and reduce feelings of anxiety or depression often associated with Kratom withdrawal.

RECOMMENDED DOSE: Follow dosing instructions on package label

How It Helps

  • Offers anti-inflammatory properties to reduce inflammation in the body
  • Supports the body’s natural healing process during recovery
  • Potential mood-supporting effects for emotional well-being
  • Note: Consume turmeric with black pepper or in combination with a fat source for enhanced curcumin absorption


Saffron, renowned for its mood-boosting properties, offers valuable support, coupled with its antioxidant benefits.

During the withdrawal phase, people may experience fluctuations in mood and feelings of emotional distress. Saffron’s bioactive compounds, including safranal and crocin, can help regulate mood by promoting the release of neurotransmitters such as serotonin and dopamine.

RECOMMENDED DOSE: Follow dosing instructions on package label

How It Helps

  • Promotes relaxation and eases restlessness
  • Alleviates anxiety symptoms during withdrawal
  • Supports healthy sleep patterns and improves sleep quality
  • Contributes to a greater sense of ease and tranquility


Gamma-Aminobutyric Acid (GABA) serves as a natural calming agent during, promoting relaxation and reducing anxiety.

GABA is an inhibitory neurotransmitter that helps regulate brain activity, calming overactive neurons and promoting a sense of tranquility. During Kratom detox, someone might experience increased anxiety and restlessness, and GABA can help alleviate these symptoms.

Amount : 1000 – 3000 mg per day in divided doses

How it Helps

  • Promotes relaxation and reduces anxiety during detox
  • Acts as a natural calming neurotransmitter to counteract excitatory signals
  • Aids in alleviating sleep disturbances for more restful recovery

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Please note: Dosage, frequency, duration, and combination recommendations of all listed products vary considerably depending upon your unique situation and needs. Check with your healthcare provider before starting any herbal or nutritional supplements, as they may interact with medications or exacerbate certain disease states.

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